3-Chlorophenylmethanesulfonyl chloride

3-Chlorophenylmethanesulfonyl chloride - Names and Identifiers

Name	3-Chlorophenylmethanesulfonyl chloride
Synonyms	3-Chlorophenylmethanesulfonyl chloride 3-Chloro-alpha-toluenesulfonyl chloride (3-chlorophenyl)methanesulfonyl chloride (3-CHLORO-PHENYL)-METHANESULFONYL CHLORIDE (3-Chloro-Phenyl)-Methanesulfonyl Chloride BENZENEMETHANESULFONYL CHLORIDE, 3-CHLORO-
CAS	24974-73-0
InChI	InChI=1/C7H6Cl2O2S/c8-7-3-1-2-6(4-7)5-12(9,10)11/h1-4H,5H2

3-Chlorophenylmethanesulfonyl chloride - Physico-chemical Properties

Molecular Formula	C7H6Cl2O2S
Molar Mass	225.09
Density	1.499±0.06 g/cm3(Predicted)
Melting Point	69-72°C
Boling Point	321.2±25.0 °C(Predicted)
Flash Point	148°C
Vapor Presure	0.000569mmHg at 25°C
Storage Condition	Room Temprature
Sensitive	Moisture Sensitive
Refractive Index	1.578
MDL	MFCD02683111

3-Chlorophenylmethanesulfonyl chloride - Risk and Safety

Risk Codes	R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R34 - Causes burns R22 - Harmful if swallowed
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
UN IDs	3261
Hazard Class	8
Packing Group	II

3-Chlorophenylmethanesulfonyl chloride - Reference Information

Application

(3-chlorophenyl) methyl sulfonyl chloride is a sulfonyl chloride compound. Sulfonyl chloride compounds are a kind of very important compounds, which are widely used as intermediates and raw materials for organic and drug synthesis, and are important sources of sulfonyl groups.

preparation

(3-chlorophenyl) methyl sulfonyl chloride is prepared as follows: thiourea (0.387g,5mmol) and m-chlorobenzyl chloride (5mmol) are dissolved in 5mL of ethanol, and after refluxing for 30min, the solvent is removed under reduced pressure to obtain a white solid. This white solid was slowly added dropwise to a mixed system of NaClO2(1.61g,15mmol,85% purity), concentrated HCl(3mL) and MeCN(10mL). During the feeding process, the temperature in the reaction system was controlled by water bath between 10 and 20oC. After the feeding is completed, the stirring reaction is continued for 30min, acetonitrile is removed under reduced pressure under low temperature conditions, 25mL of water is added, the solid in the system is filtered, and the colorless crystal (3-chlorophenyl) methylsulfonyl chloride is obtained by drying, the melting point is 76~78 ℃,1.035g, and the yield is 92%.

Last Update：2024-04-09 15:16:49